TOROMIN2018-12-10T01:28:45+00:00
Toromin

10×10 Alu/Alu

Ketorolac tromethamine     10 mg

Toromin tablet  contains Ketorolac tromethamine it may exist in three crystal forms. All forms are equally soluble in water. Ketorolac molecular weight of ketorolac tromethamine is 376.41. Its molecular formula is C19H24N2O6.Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID).

Toromin that exhibits analgesic activity  reducing hormones that cause inflammation and pain in the body. Ketorolac is used short-term (5 days or less) to treat moderate to severe pain.

  • Reduce pain
  • Reduce  inflammation
  • After medical procedures
  • After surgery

Patients age 17 to 64: 20 mg PO once followed by 10 mg q4-6 hour  prn not > 40 mg/day

Toromin tablet  is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits analgesic activity in animal models. The mechanism of action of ketorolac, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthesis inhibition. The biological activity of ketorolac tromethamine is associated with the S-form. Ketorolac tromethamine possesses no sedative or anxiolytic properties. The peak analgesic effect of ketorolac tromethamine occurs within 2 to 3 hours

Absorption

Toromin tablet is 100% absorbed after oral administration. Oral administration of ketorolac tromethamine after a high-fat meal resulted in decreased peak and delayed time-to-peak concentrations of ketorolac tromethamine by about 1 hour. Antacids did not affect the extent of absorption.

Distribution

The mean apparent volume of ketorolac tromethamine following complete distribution was approximately 13 liters. This parameter was determined from single-dose data. The ketorolac tromethamine racemate has been shown to be highly protein bound (99%). Nevertheless, plasma concentrations as high as 10 mcg/ml will only occupy approximately 5% of the albumin binding sites. Thus, the unbound fraction for each enantiomer will be constant over the therapeutic range. A decrease in serum albumin, however, will result in increased free drug concentrations.

Metabolism

Toromin tablet is largely metabolized in the liver. The metabolic products are hydroxylated and conjugated forms of the parent drug. The products of metabolism, and some unchanged drug, are excreted in the urine.

Excretion

The principal route of elimination of Toromin tablet and its metabolites is renal. About 92% of a given dose is found in the urine, approximately 40% as metabolites and 60% as unchanged ketorolac. Approximately 6% of a dose is excreted in the feces.

The half-life of the ketorolac tromethamine S-enantiomer was approximately 2.5 hours

  • peptic ulcer disease
  • gastrointestinal bleeding
  • During labor and delivery
  • Asthma
  • Worsening breathing after taking other NSAIDs
  • Bleeding or clotting problems
  • Heart disease
  • Liver disease
  • Throat, stomach, or intestinal problems
  • Stroke
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