VOXENTIN 6252018-12-10T03:36:14+00:00
Voxentin-625

1×6  aluminium strip

Amoxycillin               500 mg

Clavulanic Acid         125 mg

Amoxicillin (α-amino-p-hydroxybenzyl penicillin) is a semi synthetic derivative of penicillin. better absorption when taken by mouth.

Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete β-lactamase.

  • Bronchitis caused by the Bacteria
  • Urinary Tract Infection
  • Bacterial Urinary Tract Infection
  • Skin Infection due to
  • Bacterial Pneumonia
  • Infection of Urinary
  • Skin Infection
  • Infection of the Middle Ear
  • Acute Infection of the Nose
  • Infection of the Biliary Tract
  • Diabetic Foot Infection

Take this medication by mouth with a meal or snack, usually every 8 or 12 hours, or as directed by your doctor.

Amoxycillin 500 mg Clavulanic Acid 125 mg belonges to Penicillin group that prevents peptidoglycan from cross-linking properly in the last stages of bacterial cell wall synthesis. Peptidoglycan is a major component of most bacterial cell walls.This greatly weakens the cell wall and causes the bacterium to lyse, or burst open, because of osmotic pressure. Penicillin is bactericidal because it directly kills bacteria.

Voxentin-625 is a combination penicillin-type antibiotic used to treat a wide variety of bacterial infections. It works by stopping the growth of bacteria.This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu).

Absorption

Dosing in the fasted or fed state has minimal effect on the pharmacokinetics of amoxicillin. While amoxicillin and clavulanate potassium can be given without regard to meals, absorption of clavulanate potassium when taken with food is greater relative to the fasted state. In one study, the relative bioavailability of clavulanate was reduced when amoxicillin and clavulanate potassium was dosed at 30 and 150 minutes after the start of a high-fat breakfast.

Distribution

Neither component in amoxicillin and clavulanate potassium is highly protein-bound; clavulanic acid is approximately 25% bound to human serum and amoxicillin approximately 18% bound

Amoxicillin diffuses readily into most body tissues and fluids with the exception of the brain and spinal fluid.
Two hours after oral administration of a single 35 mg/kg dose of suspension of amoxicillin and clavulanate potassium to fasting children, average concentrations of 3 mcg/mL of amoxicillin and 0.5 mcg/mL of clavulanic acid were detected in middle ear effusions.

Metabolism and Excretion: The half-life of amoxicillin after the oral administration of amoxicillin and clavulanate potassium is 1.3 hours and that of clavulanic acid is 1 hour

  • Hypersensitivity Reactions
  • Hepatic Dysfunction
  • Allergies
  • liver disease
  • Kidney disease
  • Viral infection
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